Effects of Dopamine.HCI on Structural Parameters of Bovine Brain Membranes

Fluorescence probes located in different membrane regions were used to evaluate the effect of dopamine$.$HCI on the structural parameters (transbilayer lateral mobility, annular lipid fluidity, protein distribution, and thickness of the lipid bilayer) of synaptosomal plasma membrane vesicles (SPMV),...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2004, Vol.27 (6), p.653-661
Main Authors: Bae, Moon-Kyoung, Huh, Min-Hoi, Lee, Seung-Woo, Kang, Hyun-Gu, Pyun, Jae-Ho, Kwak, Myeong-Hee, Jang, Hye-Ock, Yun, Il
Format: Article
Language:Korean
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 661
container_issue 6
container_start_page 653
container_title Archives of pharmacal research
container_volume 27
creator Bae, Moon-Kyoung
Huh, Min-Hoi
Lee, Seung-Woo
Kang, Hyun-Gu
Pyun, Jae-Ho
Kwak, Myeong-Hee
Jang, Hye-Ock
Yun, Il
description Fluorescence probes located in different membrane regions were used to evaluate the effect of dopamine$.$HCI on the structural parameters (transbilayer lateral mobility, annular lipid fluidity, protein distribution, and thickness of the lipid bilayer) of synaptosomal plasma membrane vesicles (SPMV), which were obtained from the bovine cerebral cortex. An experimental procedure was used based on selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) by trinitrophenyl groups, and radiationless energy transfer from the tryptophan of membrane pro-teins to Py-3-Py and energy transfer from Py-3-Py monomers to 1-anilinonaphthalene-8-sulfonic acid (ANS) was also utilized. Dopamine$.$HCI increased both the bulk lateral mobility and annular lipid fluidity, and it had a greater fluidizing effect on the inner monolayer than on the outer monolayer. Furthermore, the drug had a clustering effect on membrane proteins.
format article
fullrecord <record><control><sourceid>kisti</sourceid><recordid>TN_cdi_kisti_ndsl_JAKO200411922938468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JAKO200411922938468</sourcerecordid><originalsourceid>FETCH-kisti_ndsl_JAKO2004119229384683</originalsourceid><addsrcrecordid>eNqNysEKgjAAANARBUn5D7t0NHTTuR3TjDKioO4ybYORbrHNvr-IPqDTu7wJCBKWkwjnlExBEKMMRwQRNgehc6qNM4xzQlkWgLqSUnTeQSPh1jz5oLRY78sDNBpevR07P1rewwu3fBBe2G8szOvTYGG50vAkhtZyLdwSzCTvnQh_LsBqV93KffRQzqtG313f1JvjGcVxmiQMIYZpSij-970Bk4w8OQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effects of Dopamine.HCI on Structural Parameters of Bovine Brain Membranes</title><source>Springer Nature</source><creator>Bae, Moon-Kyoung ; Huh, Min-Hoi ; Lee, Seung-Woo ; Kang, Hyun-Gu ; Pyun, Jae-Ho ; Kwak, Myeong-Hee ; Jang, Hye-Ock ; Yun, Il</creator><creatorcontrib>Bae, Moon-Kyoung ; Huh, Min-Hoi ; Lee, Seung-Woo ; Kang, Hyun-Gu ; Pyun, Jae-Ho ; Kwak, Myeong-Hee ; Jang, Hye-Ock ; Yun, Il</creatorcontrib><description>Fluorescence probes located in different membrane regions were used to evaluate the effect of dopamine$.$HCI on the structural parameters (transbilayer lateral mobility, annular lipid fluidity, protein distribution, and thickness of the lipid bilayer) of synaptosomal plasma membrane vesicles (SPMV), which were obtained from the bovine cerebral cortex. An experimental procedure was used based on selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) by trinitrophenyl groups, and radiationless energy transfer from the tryptophan of membrane pro-teins to Py-3-Py and energy transfer from Py-3-Py monomers to 1-anilinonaphthalene-8-sulfonic acid (ANS) was also utilized. Dopamine$.$HCI increased both the bulk lateral mobility and annular lipid fluidity, and it had a greater fluidizing effect on the inner monolayer than on the outer monolayer. Furthermore, the drug had a clustering effect on membrane proteins.</description><identifier>ISSN: 0253-6269</identifier><identifier>EISSN: 1976-3786</identifier><language>kor</language><ispartof>Archives of pharmacal research, 2004, Vol.27 (6), p.653-661</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4024</link.rule.ids></links><search><creatorcontrib>Bae, Moon-Kyoung</creatorcontrib><creatorcontrib>Huh, Min-Hoi</creatorcontrib><creatorcontrib>Lee, Seung-Woo</creatorcontrib><creatorcontrib>Kang, Hyun-Gu</creatorcontrib><creatorcontrib>Pyun, Jae-Ho</creatorcontrib><creatorcontrib>Kwak, Myeong-Hee</creatorcontrib><creatorcontrib>Jang, Hye-Ock</creatorcontrib><creatorcontrib>Yun, Il</creatorcontrib><title>Effects of Dopamine.HCI on Structural Parameters of Bovine Brain Membranes</title><title>Archives of pharmacal research</title><addtitle>Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea</addtitle><description>Fluorescence probes located in different membrane regions were used to evaluate the effect of dopamine$.$HCI on the structural parameters (transbilayer lateral mobility, annular lipid fluidity, protein distribution, and thickness of the lipid bilayer) of synaptosomal plasma membrane vesicles (SPMV), which were obtained from the bovine cerebral cortex. An experimental procedure was used based on selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) by trinitrophenyl groups, and radiationless energy transfer from the tryptophan of membrane pro-teins to Py-3-Py and energy transfer from Py-3-Py monomers to 1-anilinonaphthalene-8-sulfonic acid (ANS) was also utilized. Dopamine$.$HCI increased both the bulk lateral mobility and annular lipid fluidity, and it had a greater fluidizing effect on the inner monolayer than on the outer monolayer. Furthermore, the drug had a clustering effect on membrane proteins.</description><issn>0253-6269</issn><issn>1976-3786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNysEKgjAAANARBUn5D7t0NHTTuR3TjDKioO4ybYORbrHNvr-IPqDTu7wJCBKWkwjnlExBEKMMRwQRNgehc6qNM4xzQlkWgLqSUnTeQSPh1jz5oLRY78sDNBpevR07P1rewwu3fBBe2G8szOvTYGG50vAkhtZyLdwSzCTvnQh_LsBqV93KffRQzqtG313f1JvjGcVxmiQMIYZpSij-970Bk4w8OQ</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Bae, Moon-Kyoung</creator><creator>Huh, Min-Hoi</creator><creator>Lee, Seung-Woo</creator><creator>Kang, Hyun-Gu</creator><creator>Pyun, Jae-Ho</creator><creator>Kwak, Myeong-Hee</creator><creator>Jang, Hye-Ock</creator><creator>Yun, Il</creator><scope>JDI</scope></search><sort><creationdate>2004</creationdate><title>Effects of Dopamine.HCI on Structural Parameters of Bovine Brain Membranes</title><author>Bae, Moon-Kyoung ; Huh, Min-Hoi ; Lee, Seung-Woo ; Kang, Hyun-Gu ; Pyun, Jae-Ho ; Kwak, Myeong-Hee ; Jang, Hye-Ock ; Yun, Il</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kisti_ndsl_JAKO2004119229384683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2004</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bae, Moon-Kyoung</creatorcontrib><creatorcontrib>Huh, Min-Hoi</creatorcontrib><creatorcontrib>Lee, Seung-Woo</creatorcontrib><creatorcontrib>Kang, Hyun-Gu</creatorcontrib><creatorcontrib>Pyun, Jae-Ho</creatorcontrib><creatorcontrib>Kwak, Myeong-Hee</creatorcontrib><creatorcontrib>Jang, Hye-Ock</creatorcontrib><creatorcontrib>Yun, Il</creatorcontrib><collection>KoreaScience</collection><jtitle>Archives of pharmacal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bae, Moon-Kyoung</au><au>Huh, Min-Hoi</au><au>Lee, Seung-Woo</au><au>Kang, Hyun-Gu</au><au>Pyun, Jae-Ho</au><au>Kwak, Myeong-Hee</au><au>Jang, Hye-Ock</au><au>Yun, Il</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Dopamine.HCI on Structural Parameters of Bovine Brain Membranes</atitle><jtitle>Archives of pharmacal research</jtitle><addtitle>Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea</addtitle><date>2004</date><risdate>2004</risdate><volume>27</volume><issue>6</issue><spage>653</spage><epage>661</epage><pages>653-661</pages><issn>0253-6269</issn><eissn>1976-3786</eissn><abstract>Fluorescence probes located in different membrane regions were used to evaluate the effect of dopamine$.$HCI on the structural parameters (transbilayer lateral mobility, annular lipid fluidity, protein distribution, and thickness of the lipid bilayer) of synaptosomal plasma membrane vesicles (SPMV), which were obtained from the bovine cerebral cortex. An experimental procedure was used based on selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) by trinitrophenyl groups, and radiationless energy transfer from the tryptophan of membrane pro-teins to Py-3-Py and energy transfer from Py-3-Py monomers to 1-anilinonaphthalene-8-sulfonic acid (ANS) was also utilized. Dopamine$.$HCI increased both the bulk lateral mobility and annular lipid fluidity, and it had a greater fluidizing effect on the inner monolayer than on the outer monolayer. Furthermore, the drug had a clustering effect on membrane proteins.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0253-6269
ispartof Archives of pharmacal research, 2004, Vol.27 (6), p.653-661
issn 0253-6269
1976-3786
language kor
recordid cdi_kisti_ndsl_JAKO200411922938468
source Springer Nature
title Effects of Dopamine.HCI on Structural Parameters of Bovine Brain Membranes
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T09%3A11%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-kisti&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Dopamine.HCI%20on%20Structural%20Parameters%20of%20Bovine%20Brain%20Membranes&rft.jtitle=Archives%20of%20pharmacal%20research&rft.au=Bae,%20Moon-Kyoung&rft.date=2004&rft.volume=27&rft.issue=6&rft.spage=653&rft.epage=661&rft.pages=653-661&rft.issn=0253-6269&rft.eissn=1976-3786&rft_id=info:doi/&rft_dat=%3Ckisti%3EJAKO200411922938468%3C/kisti%3E%3Cgrp_id%3Ecdi_FETCH-kisti_ndsl_JAKO2004119229384683%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true