Monoamine Oxidase Inhibitory Constituents from the Fruits of Cudrania tricuspidata

A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4'-O-methylalpinumisoflavone (2), and...

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Bibliographic Details
Published in:Archives of pharmacal research 2005, Vol.28 (12), p.1324-1327
Main Authors: Han Xiang Hua, Hong Seong Su, Hwang Ji Sang, Jeong Seon Hwa, Hwang Ji Hye, Lee Min Hee, Lee Myung Koo, Lee Dongho, Ro Jai Seup, Hwang Bang Yeon
Format: Article
Language:Korean
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Summary:A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4'-O-methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with $IC_{50}$ values of 19.4, 23.9, and 25.8 $\mu$M, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B ($IC_{50}$ 0.8 $\mu$M) than MAO-A ($IC_{50}$ >800 $\mu$M). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.
ISSN:0253-6269
1976-3786