Inhibitory Activity of Isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase

The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FP...

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Bibliographic Details
Published in:Archives of pharmacal research 2005, Vol.28 (2), p.169-171
Main Authors: Oh Hyun Mi, Kwon Byoung-Mog, Baek Nam-In, Kim Sung-Hoon, Chung In-Sik, Park Mi-Hyun, Park Hee Wook, Lee Jae Hyeok, Park Hye Won, Kim Eun Jeong, Kim Dae Keun
Format: Article
Language:Korean
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Summary:The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the $IC_{50}$ value of isorhamnetin was $37.5\;{\mu}M$.
ISSN:0253-6269
1976-3786