Cytotoxic Constituents Isolated from the Fruit Bodies of Hypsizigus marmoreus

The bioactivity-guided fractionation of chloroform extracts of the fruit bodies of Hypsizigus marmoreus led to our isolation of $(22E,24R)-ergosta-7,22-diene-3{\beta},5{\alpha},6{\beta}-triol$ (1), $ergosterol-3-O-{\beta}-D-glucopyranoside$ (2), $5{\alpha},8{\alpha}-epidioxyergosta-6,22-dien-3{\beta...

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Bibliographic Details
Published in:Archives of pharmacal research 2007, Vol.30 (1), p.28-33
Main Authors: Xu, Ming-Lu, Choi, Jae-Young, Jeong, Byeong-Seon, Li, Gao, Lee, Kap-Rang, Lee, Chong-Soon, Woo, Mi-Hee, Lee, Eung-Seok, Jahng, Yurng-Dong, Chang, Hyeun-Wook, Lee, Seung-Ho, Son, Jong-Keun
Format: Article
Language:Korean
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Summary:The bioactivity-guided fractionation of chloroform extracts of the fruit bodies of Hypsizigus marmoreus led to our isolation of $(22E,24R)-ergosta-7,22-diene-3{\beta},5{\alpha},6{\beta}-triol$ (1), $ergosterol-3-O-{\beta}-D-glucopyranoside$ (2), $5{\alpha},8{\alpha}-epidioxyergosta-6,22-dien-3{\beta}-ol$ (3), hypsiziprenol $A_9$ (4), hypsiziprenol $AA_8$ (5), hypsiziprenol $AA_9$ (6) and hypsiziprenol $BA_{10}$ (7). Among these seven isolates, compound 2 was identified for the first time from this plant. All compounds (1-7) exhibited moderate cytotoxicity towards cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7) and human hepatoblastoma (HepG-2) cell lines.
ISSN:0253-6269
1976-3786