Stereoselective Synthesis of L-threo-Sphingosine, L-threo-Sphinganine, D-threo-Sphingosine, and D-threo-Sphinganine via Oxazoline Formation and Olefin Cross-Metathesis; Potent Protein Kinase C Inhibitor Analogues

In this study, we explored a convenient and concise route for synthesis of L-threo-sphingosine, D-threo-sphingosino, L-threo-sphinganine and D-threo-sphinganine from commercially available L- or D-serine. The key steps are the simple preparation of trans-oxazoline and intermolecular olefin cross met...

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Bibliographic Details
Published in:Archives of pharmacal research 2007, Vol.30 (2), p.167-171
Main Authors: Tian, Yong-Shou, Joo, Jae-Eun, Pham, Van-Thoai, Lee, Kee-Young, Ham, Won-Hun
Format: Article
Language:Korean
Online Access:Get full text
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Summary:In this study, we explored a convenient and concise route for synthesis of L-threo-sphingosine, D-threo-sphingosino, L-threo-sphinganine and D-threo-sphinganine from commercially available L- or D-serine. The key steps are the simple preparation of trans-oxazoline and intermolecular olefin cross metathesis.
ISSN:0253-6269
1976-3786