Micronucleus Test of Polycan TM , β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice

In this research the genotoxic effect of $Polycan^{TM}$ ${\beta}$-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. $Polycan^{TM}$ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclo...

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Published in:Toxicological research (Seoul) 2008, Vol.24 (1), p.11-15
Main Authors: Lee, Hyeung-Sik, Cho, Hyung-Rae, Yang, Kun-Ju, Moon, Seung-Bae, Park, Bok-Ryeon, Shin, Hyun-Dong, Jang, Hee-Jeong, Kim, Lin-Su, Ku, Sae-Kwang
Format: Article
Language:Korean
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Summary:In this research the genotoxic effect of $Polycan^{TM}$ ${\beta}$-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. $Polycan^{TM}$ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that $Polycan^{TM}$ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of $Polycan^{TM}$ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.
ISSN:1976-8257
2234-2753