Synthesis and Hypnotic Activities of N-Cbz-$\alpha$-aminoglutarimidooxy Carboxylate Derivatives

Typical hypnotic drugs, such as barbitals and glutethimide, have a cyclic imide (-CO-NH-CO-) moiety. The N-Cbz-$\alpha$-aminoglutarimidooxy carboxylate derivatives, which we previously showed exhibit moderate anticonvulsant activities, also have a cyclic imide (-CO-N-CO-) moiety. This structural sim...

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Bibliographic Details
Published in:Archives of pharmacal research 2008, Vol.31 (7), p.834-837
Main Authors: Byun, Ae-Sun, Park, Jin-Yup, Moon, Kyung-Hee, Park, Min-Soo
Format: Article
Language:Korean
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Summary:Typical hypnotic drugs, such as barbitals and glutethimide, have a cyclic imide (-CO-NH-CO-) moiety. The N-Cbz-$\alpha$-aminoglutarimidooxy carboxylate derivatives, which we previously showed exhibit moderate anticonvulsant activities, also have a cyclic imide (-CO-N-CO-) moiety. This structural similarity prompted us to examine the hypnotic activities of the N-Cbz-$\alpha$-aminoglutarimidooxy carboxylate derivatives, and we describe their moderate hypnotic activities here.
ISSN:0253-6269
1976-3786