Small GTPases and formins in mammalian oocyte maturation: cytoskeletal organizers

The maturation process of mammalian oocytes accompanies an extensive rearrangement of the cytoskeleton and associated proteins. As this process requires a delicate interplay between the cytoskeleton and its regulators, it is often targeted by various external and internal adversaries that affect the...

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Bibliographic Details
Published in:Clinical and experimental reproductive medicine 2011, Vol.38 (1), p.1-5
Main Authors: Kwon, So-Jung, Lim, Hyun-Jung J
Format: Article
Language:Korean
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Summary:The maturation process of mammalian oocytes accompanies an extensive rearrangement of the cytoskeleton and associated proteins. As this process requires a delicate interplay between the cytoskeleton and its regulators, it is often targeted by various external and internal adversaries that affect the congression and/or segregation of chromosomes. Asymmetric cell division in oocytes also requires specific regulators of the cytoskeleton, including formin-2 and small GTPases. Recent literature providing clues regarding how actin filaments and microtubules interact during spindle migration in mouse oocytes are highlighted in this review.
ISSN:2233-8233
2233-8241