Inertial Dynamic Effect on the Rates of Diffusion-Controlled Ligand-Receptor Reactions

It has been known that the inertial dynamics has a little effect on the reaction rate in solutions. In this work, however, we find that for diffusion-controlled reactions between a ligand and a receptor on the cell surface there is a noticeable inertial dynamic effect on the reaction rate. We estima...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2011, Vol.32 (8), p.2973-2977
Main Authors: Lee, Woo-Jin, Kim, Ji-Hyun, Lee, Sang-Youb
Format: Article
Language:Korean
Online Access:Get full text
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Summary:It has been known that the inertial dynamics has a little effect on the reaction rate in solutions. In this work, however, we find that for diffusion-controlled reactions between a ligand and a receptor on the cell surface there is a noticeable inertial dynamic effect on the reaction rate. We estimate the magnitude of the inertial dynamic effect by comparing the approximate analytic results obtained with and without the inertial dynamic effect included. The magnitude of the inertial dynamic effect depends on the friction coefficient of the ligand as well as on the relative scale of the receptor size to the distance traveled by the ligand during its velocity relaxation time.
ISSN:0253-2964
1229-5949