Immunotherapeutic Approach for Better Management of Cancer - Role of IL-18

Interleukin-18 (IL-18) is an immune-stimulatory cytokine with antitumor activity in preclinical models. It plays pivotal roles in linking inflammatory immune responses and tumor progression and is a useful candidate in gene therapy of lymphoma or lymphoid leukemia. A phase I study of recombinant hum...

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Bibliographic Details
Published in:Asian Pacific journal of cancer prevention : APJCP 2012, Vol.13 (11), p.5353-5361
Main Authors: Kuppala, Manohar Babu, Syed, Sunayana Begum, Bandaru, Srinivas, Varre, Sreedevi, Akka, Jyothy, Mundulru, Hema Prasad
Format: Article
Language:Korean
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Summary:Interleukin-18 (IL-18) is an immune-stimulatory cytokine with antitumor activity in preclinical models. It plays pivotal roles in linking inflammatory immune responses and tumor progression and is a useful candidate in gene therapy of lymphoma or lymphoid leukemia. A phase I study of recombinant human IL-18 (rhIL-18) in patients with advanced cancer concluded that rhIL-18 can be safely given in biologically active doses to patients with advanced cancer. Some viruses can induce the secretion of IL-18 for immune evasion. The individual cytokine activity might be potentiated or inhibited by combinations of cytokines. Here we focus on combinational effects of cytokines with IL-18 in cancer progression. IL-18 is an important non-invasive marker suspected of contributing to metastasis. Serum IL-18 may a useful biological marker as independent prognostic factor of survival. In this review we cover roles of IL-18 in immune evasion, metastasis and angiogenesis, applications for chemotherapy and prognostic or diagnostic significance.
ISSN:1513-7368
2476-762X