Anti-inflammatory activity of Camellia japonica oil

Camellia japonica oil (CJ oil) has been used traditionally in East Asia to nourish and soothe the skin as well as help restore the elasticity of skin. CJ oil has also been used on all types of bleeding instances. However, little is known about its anti-inflammatory effects. Therefore, the anti-infla...

Full description

Saved in:
Bibliographic Details
Published in:BMB reports 2012-03, Vol.45 (3), p.177-182
Main Authors: Kim, Seung-Beom, Jung, Eun-Sun, Shin, Seung-Woo, Kim, Moo-Han, Kim, Young-Soo, Lee, Jong-Sung, Park, Deok-Hoon
Format: Article
Language:Korean
Subjects:
AP-1
Camellia japonica oil
COX-2
iNOS
NF-κB
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Camellia japonica oil (CJ oil) has been used traditionally in East Asia to nourish and soothe the skin as well as help restore the elasticity of skin. CJ oil has also been used on all types of bleeding instances. However, little is known about its anti-inflammatory effects. Therefore, the anti-inflammatory effects of CJ oil and its mechanisms of action were investigated. CJ oil inhibited LPS-induced production of NO, PGE2, and TNF-α in RAW264.7 cells. In addition, expression of COX-2 and iNOS genes was reduced. To evaluate the mechanism of the anti-inflammatory activity of CJ oil, LPS-induced activation of AP-1 and NF-κB promoters was found to be significantly reduced by CJ oil. LPS-induced phosphorylation of IκBα, ERK, p38, and JNK was also attenuated. Our results indicate that CJ oil exerts anti-inflammatory effects by downregulating the expression of iNOS and COX-2 genes through inhibition of NF-κB and AP-1 signaling. [BMB reports 2012; 45(3): 177-182]
ISSN:1976-6696
1976-670X