Design, Synthesis and In Vitro Cytotoxic Activity Evaluation of New Mannich Bases

A series of Novel Mannich bases has been synthesized and evaluated $in$ $vitro$ cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1), and human breast cancer (MCF-7). Compound $\mathbf{9f}$ was found to be most potent against three cell lines with $IC...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2012, Vol.33 (5), p.1586-1592
Main Authors: Bui, Trung Hieu, Le, Thi Thuy, Vu, Thu Thuy, Hoang, Xuan Tien, Luu, Van Chinh, Vu, Dinh Hoang, Tran, Khac Vu
Format: Article
Language:Korean
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Summary:A series of Novel Mannich bases has been synthesized and evaluated $in$ $vitro$ cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1), and human breast cancer (MCF-7). Compound $\mathbf{9f}$ was found to be most potent against three cell lines with $IC_{50}$ values of 1.57, 1.16 and 1.21 ${\mu}g$/mL, respectively. In addition, compounds $\mathbf{9g}$, $\mathbf{10f}$ exhibited very significant activity against MCF-7 cell line with $IC_{50}$ values of 2.0 ${\mu}g$/mL.
ISSN:0253-2964
1229-5949