Synthesis of Small Molecule-Peptide Conjugates as Potential Whitening Agents

Small molecule conjugated peptides were prepared by solid-phase synthesis as potential novel whitening agents, and their melanogenesis inhibitory activities were investigated. The conjugated small molecules were well-known materials as tyrosinase inhibitors, and peptides were selected from the seque...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2012, Vol.33 (9), p.3004-3008
Main Authors: Lee, Hye-Suk, Shin, Kyong-Hoon, Ryu, Geun-Seok, Chi, Gyeong-Yup, Cho, In-Shik, Kim, Han-Young
Format: Article
Language:Korean
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Summary:Small molecule conjugated peptides were prepared by solid-phase synthesis as potential novel whitening agents, and their melanogenesis inhibitory activities were investigated. The conjugated small molecules were well-known materials as tyrosinase inhibitors, and peptides were selected from the sequences that are known to antagonize melanocortin receptor 1 (MC1R). Most of small molecules-peptide conjugates showed superior melanin inhibition activity to kojic acid and arbutin. Among these, almost all compounds have -AR- sequence. From this study, we concluded that the small molecule conjugated peptides containing -AR- sequence have melanogenesis inhibitory activities and have potential to be used as novel whitening agents.
ISSN:0253-2964
1229-5949