Glutathione S-Transferase Expression in Upper Urinary Tract Urothelial Carcinomas: a Taiwan Study

Objectives: Glutathione S-transferase (GST) isoenzymes play important roles in resistance to cell apoptosis and carcinogenesis. We aimed to establish the relationship between GST expression and the prognosis of upper urinary tract urothelial carcinoma (UTT-UC) in Taiwan. Methods: This study retrospe...

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Published in:Asian Pacific journal of cancer prevention : APJCP 2013, Vol.14 (11), p.6475-6479
Main Authors: Chen, Szu-Han, Wu, Wen-Jeng, Tu, Hung-Pin, Li, Wei-Ming, Huang, Chun-Nung, Li, Ching-Chia, Lin, Hui-Hui, Ke, Hung-Lung
Format: Article
Language:Korean
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Summary:Objectives: Glutathione S-transferase (GST) isoenzymes play important roles in resistance to cell apoptosis and carcinogenesis. We aimed to establish the relationship between GST expression and the prognosis of upper urinary tract urothelial carcinoma (UTT-UC) in Taiwan. Methods: This study retrospectively reviewed 46 patients with pathologically confirmed UUT-UC at Kaohsiung Medical University Hospital. In each patient, expression of GSTT1 and GSTP1 was compared between urothelial carcinoma and normal urothelial cells by Western blotting. Results: GSTP1 expression in the UUT-UC cells was significantly higher than that in normal urothelial cells (1.6 fold, p
ISSN:1513-7368
2476-762X