Synthesis of Ergosterol and 5,6-Dihydroergosterol Glycosides and Their Inhibitory Activities on Lipopolysaccharide-Induced Nitric Oxide Production

We have synthesized several glycosyl ergosterols and 5,6-dihydroergosterols (DHE) and examined their effects on production of nitric oxide (NO) and iNOS protein expression in LPS-treated RAW264.7 macrophage cells. Our results showed that DHE derivatives inhibited production of NO and iNOS protein ex...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2013, Vol.34 (5), p.1339-1344
Main Authors: Park, HoonGyu, Lee, Tae Hoon, Chang, Fei, Kwon, Hyun Ji, Kim, Jiyoung, Kim, Hakwon
Format: Article
Language:Korean
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Summary:We have synthesized several glycosyl ergosterols and 5,6-dihydroergosterols (DHE) and examined their effects on production of nitric oxide (NO) and iNOS protein expression in LPS-treated RAW264.7 macrophage cells. Our results showed that DHE derivatives inhibited production of NO and iNOS protein expression more strongly than ergosterol derivative. Especially, DHE-Glc exhibited most potent inhibitory activity without cytotoxicity up to the concentration of $100{\mu}M$.
ISSN:0253-2964
1229-5949