Synthesis of Ergosterol and 5,6-Dihydroergosterol Glycosides and Their Inhibitory Activities on Lipopolysaccharide-Induced Nitric Oxide Production

We have synthesized several glycosyl ergosterols and 5,6-dihydroergosterols (DHE) and examined their effects on production of nitric oxide (NO) and iNOS protein expression in LPS-treated RAW264.7 macrophage cells. Our results showed that DHE derivatives inhibited production of NO and iNOS protein ex...

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Published in:Bulletin of the Korean Chemical Society 2013, Vol.34 (5), p.1339-1344
Main Authors: Park, HoonGyu, Lee, Tae Hoon, Chang, Fei, Kwon, Hyun Ji, Kim, Jiyoung, Kim, Hakwon
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container_title Bulletin of the Korean Chemical Society
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creator Park, HoonGyu
Lee, Tae Hoon
Chang, Fei
Kwon, Hyun Ji
Kim, Jiyoung
Kim, Hakwon
description We have synthesized several glycosyl ergosterols and 5,6-dihydroergosterols (DHE) and examined their effects on production of nitric oxide (NO) and iNOS protein expression in LPS-treated RAW264.7 macrophage cells. Our results showed that DHE derivatives inhibited production of NO and iNOS protein expression more strongly than ergosterol derivative. Especially, DHE-Glc exhibited most potent inhibitory activity without cytotoxicity up to the concentration of $100{\mu}M$.
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title Synthesis of Ergosterol and 5,6-Dihydroergosterol Glycosides and Their Inhibitory Activities on Lipopolysaccharide-Induced Nitric Oxide Production
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