시스플라틴 항암제에 의해 유발되는 식욕부진과 신경병증성 통증이 쥐의 뒷다리근에 미치는 영향

• Published in: Journal of Korean Academy of Nursing 2013-06, Vol.43 (3), p.361-369
• Main Authors: 양지수, 최명애, Yang, Gee Su, Choe, Myoung-Ae
• Format: Article
• Language: Korean
• ISSN: 2005-3673; 2093-758X

Purpose: The purpose of this study was to examine the effect of anorexia and neuropathic pain induced by cisplatin on hindlimb muscles of rats. Methods: Adult male Sprague-Dawley rats were divided into two groups, a cisplatin-treated group (n=10) and a control group (n=10). In the cisplatin-treated group, cisplatin at a dose of 2 mg/kg was injected intraperitoneally two times a week up to a cumulative dose of 20 mg/kg over 5 weeks, and in the control group saline (0.9% NaCl) was injected intraperitoneally at the same dose and duration as the cisplatin-treated group. At 34 days all rats were anesthetized, after which the soleus and plantaris muscles were dissected. Withdrawal threshold, body weight, food intake, activity, muscle weight, Type I and II fiber cross-sectional areas and myofibrillar protein content of the dissected muscles were determined. Results: Compared with the control group, the cisplatin-treated group showed significant decreases (p