Dependence Potential of Quetiapine: Behavioral Pharmacology in Rodents

Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine`s d...

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Bibliographic Details
Published in:Biomolecules & therapeutics 2013-07, Vol.21 (4), p.307-312
Main Authors: Cha, Hye Jin, Lee, Hyun-A, Ahn, Joon-Ik, Jeon, Seol-Hee, Kim, Eun Jung, Jeong, Ho-Sang
Format: Article
Language:Korean
Subjects:
Animal behavioral tests
Dopamine system
Drug dependence
Quetiapine
Serotonin system
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Summary:Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine`s dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to fi nd out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed signifi cant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.
ISSN:1976-9148
2005-4483