Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In...

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Bibliographic Details
Published in:BMB reports 2013-09, Vol.46 (9), p.460-464
Main Authors: Shin, Hyoseung, Yoo, Hyeon Gyeong, Inui, Shigeki, Itami, Satoshi, Kim, In Gyu, Cho, A-Ri, Lee, Dong Hun, Park, Won Seok, Kwon, Ohsang, Cho, Kwang Hyun, Won, Chong Hyun
Format: Article
Language:Korean
Subjects:
Androgen receptor
Androgenetic alopecia
Dermal papilla
Reactive oxygen species
Transforming growth factors
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Summary:The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF-β1 secretion is increased by androgen treatment in DP-6, whereas androgeninducible TGF-β1 was significantly suppressed by the ROSscavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF-β1 by androgen is mediated by ROS in hair follicle DPCs. [BMB Reports 2013; 46(9): 460-464]
ISSN:1976-6696
1976-670X