Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin

We investigated the inhibitory effects of hesperidin on melanogenesis. To fi nd melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for R...

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Bibliographic Details
Published in:Biomolecules & therapeutics 2013-09, Vol.21 (5), p.343-348
Main Authors: Kim, Bora, Lee, Jee-Young, Lee, Ha-Yeon, Nam, Ky-Youb, Park, JongIl, Lee, Su Min, Kim, Jin Eun, Lee, Joo Dong, Hwang, Jae Sung
Format: Article
Language:Korean
Subjects:
Hesperidin
Melanophilin
Melanosome transport
Pigmented reconstructed epidermis model
Rab27A
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Summary:We investigated the inhibitory effects of hesperidin on melanogenesis. To fi nd melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.
ISSN:1976-9148
2005-4483