A Facial Protocol for the Synthesis of Benzofuran Derivatives by the Reaction of o-Hydroxy Aryl Ketone, Amine and Chloroacetyl Chloride

A facile and effective method has been developed for the synthesis of a novel series of benzofuran derivatives via N-acylation, O-alkylation and intramolecular condensation reactions, starting from readily available substituted o-hydroxy aryl ketone, and chloroacetyl arylamides. This metal-free tran...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2014, Vol.35 (6), p.1743-1748
Main Authors: Xia, Shuai, Wang, Xiu-Hua, Liu, Ji-Qiang, Liu, Chang, Chen, Jian-Bin, Zuo, Hua, Xie, Yong-Sheng, Dong, Wen-Liang, Shin, Dong-Soo
Format: Article
Language:Korean
Online Access:Get full text
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Summary:A facile and effective method has been developed for the synthesis of a novel series of benzofuran derivatives via N-acylation, O-alkylation and intramolecular condensation reactions, starting from readily available substituted o-hydroxy aryl ketone, and chloroacetyl arylamides. This metal-free transition process is characterized by mild reaction conditions, atom economy, short reaction time and a high yield with a decreased amount of by-products.
ISSN:0253-2964
1229-5949