Schedule-Dependent Effect of Epigallocatechin-3-Gallate (EGCG) with Paclitaxel on H460 Cells

Background: Epigallocatechin-3-gallate (EGCG), a major biologically active component of green tea, has anti-cancer activity in human and animal models. We investigated the schedule-dependent effect of EGCG and paclitaxel on growth of NCI-H460 non-small cell lung cancer cells. Methods: To investigate...

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Bibliographic Details
Published in:Tuberculosis and respiratory diseases 2014-03, Vol.76 (3), p.114-119
Main Authors: Park, Sunghoon, Kim, Joo-Hee, Hwang, Yong Il, Jung, Ki-Suck, Jang, Young Sook, Jang, Seung Hun
Format: Article
Language:Korean
Subjects:
Cell Cycle
Epigallocatechin Gallate
Lung Neoplasms
Paclitaxel
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Summary:Background: Epigallocatechin-3-gallate (EGCG), a major biologically active component of green tea, has anti-cancer activity in human and animal models. We investigated the schedule-dependent effect of EGCG and paclitaxel on growth of NCI-H460 non-small cell lung cancer cells. Methods: To investigate the combined effect of EGCG (E) and paclitaxel (P), combination indices (CIs) were calculated, and cell cycle analysis was performed. For the effect on cell apoptosis, western blot analysis was also performed. Results: CI analysis demonstrated that both concurrent and sequential E → P treatments had antagonistic effects (CIs >1.0), but sequential P → E had synergistic effects (CIs
ISSN:1738-3536
2005-6184