RNA Interference: a Promising Therapy for Gastric Cancer

Gastric cancer (GC) remains a virtually incurable disease when metastatic and requires early screening tools for detection of early tumor stages. Therefore, finding effective strategies for prevention or recurrence of GC has become a major overall initiative. RNA-interference (RNAi) is an innovative...

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Bibliographic Details
Published in:Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 (14), p.5509-5515
Main Authors: Felipe, Aledson Vitor, Oliveira, Juliana de, Chang, Paula Yun Joo, Moraes, Andrea Aparecida de Fatima Souza, Silva, Tiago Donizetti da, Tucci-Viegas, Vanina Monique, Forones, Nora Manoukian
Format: Article
Language:Korean
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Summary:Gastric cancer (GC) remains a virtually incurable disease when metastatic and requires early screening tools for detection of early tumor stages. Therefore, finding effective strategies for prevention or recurrence of GC has become a major overall initiative. RNA-interference (RNAi) is an innovative technique that can significantly regulate the expression of oncogenes involved in gastric carcinogenesis, thus constituting a promising epigenetic approach to GC therapy. This review presents recent advances concerning the promising biomolecular mechanism of RNAi for GC treatment.
ISSN:1513-7368
2476-762X