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Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells
Melanoma is the most aggressive skin cancer and its incidence is gradually increasing worldwide. Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of
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| Published in: | Immune network 2015, Vol.15 (2), p.58-65 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | Korean |
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| container_end_page | 65 |
| container_issue | 2 |
| container_start_page | 58 |
| container_title | Immune network |
| container_volume | 15 |
| creator | Kim, Ji Sung Kim, Yong Guk Pyo, Minji Lee, Hong Kyung Hong, Jin Tae Kim, Youngsoo Han, Sang-Bae |
| description | Melanoma is the most aggressive skin cancer and its incidence is gradually increasing worldwide. Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of |
| format | article |
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Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of <16%). In the last few years, several drugs have been approved for malignant melanoma, such as tyrosine kinase inhibitors and immune checkpoint blockades. Although new therapeutic agents have improved progression-free and overall survival, their use is limited by drug resistance and drug-related toxicity. At the same time, adoptive cell therapy of metastatic melanoma with tumor-infiltrating lymphocytes has shown promising results in preclinical and clinical studies. In this review, we summarize the currently available drugs for treatment of malignant melanoma. In addition, we suggest cytokine-induced killer (CIK) cells as another candidate approach for adoptive cell therapy of melanoma. 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Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of <16%). In the last few years, several drugs have been approved for malignant melanoma, such as tyrosine kinase inhibitors and immune checkpoint blockades. Although new therapeutic agents have improved progression-free and overall survival, their use is limited by drug resistance and drug-related toxicity. At the same time, adoptive cell therapy of metastatic melanoma with tumor-infiltrating lymphocytes has shown promising results in preclinical and clinical studies. In this review, we summarize the currently available drugs for treatment of malignant melanoma. In addition, we suggest cytokine-induced killer (CIK) cells as another candidate approach for adoptive cell therapy of melanoma. Our preclinical study and several previous studies have shown that CIK cells have potent anti-tumor activity against melanomas in vitro and in an in vivo human tumor xenograft model without any toxicity.</abstract><oa>free_for_read</oa></addata></record> |
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| ispartof | Immune network, 2015, Vol.15 (2), p.58-65 |
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| title | Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells |
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