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IL-35 Over-expression is Associated with Genesis of Gastric Cancer
Overexpression of interleukin (IL)-35 has been found in a variety of malignancies, but the expression status in gastric cancer has yet to be elucidated clearly. In the present study, positive expression of EBI3 and p35 was 63.3% and 70.0% of cases, respectively. EBI3 expression was strongly related...
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Published in: | Asian Pacific journal of cancer prevention : APJCP 2015, Vol.16 (7), p.2845-2849 |
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container_title | Asian Pacific journal of cancer prevention : APJCP |
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creator | Fan, Yong-Gang Zhai, Jing-Ming Wang, Wei Feng, Bing Yao, Guo-Liang An, Yan-Hui Zeng, Chao |
description | Overexpression of interleukin (IL)-35 has been found in a variety of malignancies, but the expression status in gastric cancer has yet to be elucidated clearly. In the present study, positive expression of EBI3 and p35 was 63.3% and 70.0% of cases, respectively. EBI3 expression was strongly related with larger tumor size and invasion depth (P |
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In the present study, positive expression of EBI3 and p35 was 63.3% and 70.0% of cases, respectively. EBI3 expression was strongly related with larger tumor size and invasion depth (P<0.05). Similarly, expression of p35 was also correlated with larger tumor size (P<0.05). These results indicate that IL-35 might be involved in growth of gastric cancer. Interestingly, EBI3 and p35 expressions were positive correlated with Ki-67 expression. Moreover, EBI3 immunoreactivity was associated with Bcl-2 staining. 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title | IL-35 Over-expression is Associated with Genesis of Gastric Cancer |
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