Isoprenylated flavonoids from the root bark of Morus alba L. and their inhibition effect on NO production in LPS-induced RAW 264.7 cells

The root bark of Morus alba L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H 2 O fractions. The repeated silica gel (SiO 2 ), octadecyl SiO 2 (ODS), and Sephadex LH-20 column chromatographies of the EtOAc fraction led to isolation of 12...

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Bibliographic Details
Published in:Journal of applied biological chemistry 2017-06, Vol.60 (2), p.109-111
Main Authors: Jung, Jae-Woo, Ko, Jung-Hwan, Ko, Won-Min, Park, Ji-Hae, Baek, Yun-Su, Kim, Youn-Chul, Baek, Nam-In
Format: Article
Language:Korean
Subjects:
Anti-inflammatory · Isoprenylated flavonoid · Morus alba · Nitric oxide production · RAW 264.7 · Root bark
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Summary:The root bark of Morus alba L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H 2 O fractions. The repeated silica gel (SiO 2 ), octadecyl SiO 2 (ODS), and Sephadex LH-20 column chromatographies of the EtOAc fraction led to isolation of 12 phenolic compounds. The chemical structures of the compounds were determined as sanggenol Q (1), sanggenol A (2), sanggenol L (3), kuwanon T (4), cyclomorusin (5), sanggenon F (6), sanggenol O (7), sanggenon N (8), sanggenon G (9), mulberrofuran G (10), mulberrofuran C (11), and moracin E (12). All isolated compounds were evaluated for inhibit lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.
ISSN:1976-0442
2234-7941