In vivo micronucleus test of 4-butylaniline and N-butylaniline to classify a chemical’s mutagenicity according to the globally harmonized system of classification and labelling of chemicals (GHS)

In vivo micronucleus tests were performed to investigate the mutagenic potential of 4-butylaniline and N-butylaniline, which are used in dye intermediates and organic intermediates respectively. Groups of 5 male ICR mice were treated with vehicle or 4-butylaniline for 2 consecutive days by oral gava...

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Bibliographic Details
Published in:Journal of applied biological chemistry 2019-12, Vol.62 (4), p.355-359
Main Authors: Kim, Soo-Jin, Shin, Seo-ho, Kim, Hyun-ock, Rim, Kyung-Taek
Format: Article
Language:Korean
Subjects:
4-butylaniline
Genotoxicity
Micronucleus assay
N-butylaniline
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Summary:In vivo micronucleus tests were performed to investigate the mutagenic potential of 4-butylaniline and N-butylaniline, which are used in dye intermediates and organic intermediates respectively. Groups of 5 male ICR mice were treated with vehicle or 4-butylaniline for 2 consecutive days by oral gavage at concentrations of 0 (control), 64, 160, 400, and 1000 mg/kg. Statistically significant and dose-dependent increases were found for micronuclei frequencies in male mice (p
ISSN:1976-0442
2234-7941