Investigation of the effect of Staufen1 overexpression on the HIV-1 virus production

In this study, we investigated how Staufen1 influences the HIV-1 production. The overexpression of Staufen1 increased virus production without any negative affect on the viral infectivity. This increase was not caused by transcriptional activation; but by influencing post-transcriptional steps. Usin...

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Bibliographic Details
Published in:BMB reports 2021-11, Vol.54 (11), p.551-556
Main Authors: Park, Seong-won, Yu, Kyung-Lee, Bae, Jun-Hyun, Kim, Ga-Na, Kim, Hae-In, You, Ji Chang
Format: Article
Language:Korean
Subjects:
HIV-1
RNA-binding proteins
Staufen1
Virus replication
Virus-host interaction
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Summary:In this study, we investigated how Staufen1 influences the HIV-1 production. The overexpression of Staufen1 increased virus production without any negative affect on the viral infectivity. This increase was not caused by transcriptional activation; but by influencing post-transcriptional steps. Using multiple Gag protein derivatives, we confirmed that the zinc-finger domains of the HIV-1 nucleocapsid (NC) are important for its interaction with Staufen1. We also found that Staufen1 colocalized in stress granules with the mature form of the HIV-1 NC protein. [BMB Reports 2021; 54(11): 551-556]
ISSN:1976-6696
1976-670X