Hygrolansamycins A-D, O-Heterocyclic Macrolides from Streptomyces sp. KCB17JA11

Six ansamycin derivatives were isolated from the culture broth of Streptomyces sp. KCB17JA11, including four new hygrolansamycins A-D (1-4) and known congeners divergolide O (5) and hygrocin C (6). Compounds 1-5 featured an unusual six-membered O-heterocyclic moiety. The isolation workflow was guide...

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Bibliographic Details
Published in:Journal of microbiology and biotechnology 2022-10, Vol.32 (10), p.1299-1306
Main Authors: Jang, Jun-Pil, Lee, Byeongsan, Heo, Kyung Taek, Oh, Tae Hoon, Lee, Hyeok-Won, Ko, Sung-Kyun, Hwang, Bang Yeon, Jang, Jae-Hyuk, Hong, Young-Soo
Format: Article
Language:Korean
Subjects:
ansamycin family
hygrolansamycin
Molecular networking
Streptomyces
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Summary:Six ansamycin derivatives were isolated from the culture broth of Streptomyces sp. KCB17JA11, including four new hygrolansamycins A-D (1-4) and known congeners divergolide O (5) and hygrocin C (6). Compounds 1-5 featured an unusual six-membered O-heterocyclic moiety. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The structures of 1-4 were elucidated using NMR and HRESIMS experiments, and the absolute configuration was established by the Mosher’s method. Compound 2 exhibited mild cytotoxicity against five cancer cell lines with IC 50 values ranging from 24.60 ± 3.37 μM to 49.93 ± 4.52 μM.
ISSN:1017-7825
1738-8872