In Vivo Effects of Crataegus pinnatifida Extract for Healthy Longevity

Aging is a complex series of multi-organ processes that occur in various organisms. As such, an in vivo study using an animal model of aging is necessary to define its exact mechanisms and identify anti-aging substances. Using Drosophila as an in vivo model system, we identified Crataegus pinnatifid...

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Bibliographic Details
Published in:Journal of microbiology and biotechnology 2023-05, Vol.33 (5), p.680-686
Main Authors: In-sun Yu, Mina K. Kim, Min Jung Kim, Jaewon Shim
Format: Article
Language:Korean
Subjects:
Crataegus pinnatifida
drosophila melanogaster
Healthy longevity
nutrient-sensing pathway
oxidative stress resistance
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Summary:Aging is a complex series of multi-organ processes that occur in various organisms. As such, an in vivo study using an animal model of aging is necessary to define its exact mechanisms and identify anti-aging substances. Using Drosophila as an in vivo model system, we identified Crataegus pinnatifida extract (CPE) as a novel anti-aging substance. Regardless of sex, Drosophila treated with CPE showed a significantly increased lifespan compared to those without CPE. In this study, we also evaluated the involvement of CPE in aging-related biochemical pathways, including TOR, stem cell generation, and antioxidative effects, and found that the representative genes of each pathway were induced by CPE administration. CPE administration did not result in significant differences in fecundity, locomotion, feeding amount, or TAG level. These conclusions suggest that CPE is a good candidate as an anti-aging food substance capable of promoting a healthy lifespan.
ISSN:1017-7825
1738-8872