Rutin alleviated lipopolysaccharide-induced damage in goat rumen epithelial cells

Objective: Rutin, also called vitamin P, is a flavonoids from plants. Previous studies have indicated that rutin can alleviate the injury of tissues and cells by inhibiting oxidative stress and ameliorating inflammation. There is no report on the protective effects of rutin on goat rumen epithelial...

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Bibliographic Details
Published in:Animal bioscience 2024, Vol.37 (2), p.303-314
Main Authors: Jinshun Zhan, Zhiyong Gu, Haibo Wang, Yuhang Liu, Yanping Wu, Junhong Huo
Format: Article
Language:Korean
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Summary:Objective: Rutin, also called vitamin P, is a flavonoids from plants. Previous studies have indicated that rutin can alleviate the injury of tissues and cells by inhibiting oxidative stress and ameliorating inflammation. There is no report on the protective effects of rutin on goat rumen epithelial cells (GRECs) at present. Hence, we investigated whether rutin can alleviate lipopolysaccharide (LPS)-induced damage in GRECs. Methods: GRECs were cultured in basal medium or basal medium containing 1 ㎍/mL LPS, or 1 ㎍/mL LPS and 20 ㎍/mL rutin. Six replicates were performed for each group. After 3-h culture, the GRECs were harvested to detect the relevant parameters. Results: Rutin significantly enhanced the cell activity (p
ISSN:2765-0189
2765-0235