Association between Transfusion-Related Iron Overload and Liver Fibrosis in Survivors of Pediatric Leukemia: A Cross-Sectional Study

Purpose: Patients who receive frequent blood transfusions are at an elevated risk of developing hepatic fibrosis due to iron overload in the liver. In this study, we evaluated the effectiveness of transient elastography (TE) (FibroScan®) for assessing liver fibrosis in patients with pediatric cancer...

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Published in:Pediatric gastroenterology, hepatology & nutrition hepatology & nutrition, 2024, Vol.27 (4), p.215-223
Main Authors: Mahsa Sobhani, Naser Honar, Mohammadreza Fattahi, Sezaneh Haghpanah, Nader Shakibazad, Mohammadreza Bordbar
Format: Article
Language:Korean
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Summary:Purpose: Patients who receive frequent blood transfusions are at an elevated risk of developing hepatic fibrosis due to iron overload in the liver. In this study, we evaluated the effectiveness of transient elastography (TE) (FibroScan®) for assessing liver fibrosis in patients with pediatric cancer. Methods: We enrolled 106 consecutive cases of acute leukemia in individuals under 21 years of age. The participants were followed for 2 years. Based on their serum ferritin (SF) levels, the patients were divided into two groups: group 1 (SF≥300 ng/mL) and group 2 (SF
ISSN:2234-8646
2234-8840