Circulating tumor cells count and characterization in a male breast cancer patient

A 64-y-old man presented to Medical Oncology Department a metastatic invasive ductal breast carcinoma, positive for estrogen (ER) and progesterone receptors (PR) and Her2/neu negative. The patient was treated with different lines of therapy, with rapid radiological progression of disease. After four...

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Bibliographic Details
Published in:Cancer biology & therapy 2011-09, Vol.12 (5), p.379-382
Main Authors: Gazzaniga, Paola, Naso, Giuseppe, Raimondi, Cristina, Gradilone, Angela, Palazzo, Antonella, Gandini, Orietta, Petracca, Arianna, Nicolazzo, Chiara, Cortesi, Enrico, Frati, Luigi
Format: Article
Language:English
Subjects:
Binding
Biology
Bioscience
Breast Neoplasms, Male - blood
Breast Neoplasms, Male - drug therapy
Calcium
Cancer
Carboplatin - administration & dosage
Carboplatin - pharmacology
Carboplatin - therapeutic use
Carcinoma, Ductal, Breast - blood
Carcinoma, Ductal, Breast - drug therapy
Cell
Cell Count
Cycle
Deoxycytidine - administration & dosage
Deoxycytidine - analogs & derivatives
Deoxycytidine - pharmacology
Deoxycytidine - therapeutic use
Docetaxel
Drug Resistance, Neoplasm
Epirubicin - administration & dosage
Epirubicin - pharmacology
Epirubicin - therapeutic use
Humans
Landes
Male
Middle Aged
Neoplastic Cells, Circulating - drug effects
Organogenesis
Prognosis
Proteins
Receptor, ErbB-2 - biosynthesis
Receptors, Estrogen - biosynthesis
Receptors, Progesterone - biosynthesis
Taxoids - administration & dosage
Taxoids - pharmacology
Taxoids - therapeutic use
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Description
Summary:A 64-y-old man presented to Medical Oncology Department a metastatic invasive ductal breast carcinoma, positive for estrogen (ER) and progesterone receptors (PR) and Her2/neu negative. The patient was treated with different lines of therapy, with rapid radiological progression of disease. After four courses of a third-line chemotherapy, a radiological stable disease was maintained. The patient was followed by serial blood drawings for the characterization and count of circulating tumor cells (CTC). This is the first report concerning the predictive and prognostic value of CTC in a male breast cancer patient.
ISSN:1538-4047
1555-8576
DOI:10.4161/cbt.12.5.16304