A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy: Understanding the Oct 3/4 and Sox 2 interaction

Extragonadal germ cell tumors (EGCTs) in the lung are extremely rare and their pathogenesis is poorly understood. We report a case in a 48-year-old female which was very aggressive and stained positive for primoridial germ cell markers. Interestingly, there was chromosome 3 polysomy noted. To our kn...

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Bibliographic Details
Published in:Cancer biology & therapy 2013-01, Vol.14 (1), p.0-1
Main Authors: Frantz Duffoo, Mike Macera, Sneha Mishra, Amita Kalra, Pervez Mir, Afaf Abdu, Shitij Arora, Harinder Sawhney, Harish Patel, William Thelmo
Format: Article
Language:English
Subjects:
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
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Summary:Extragonadal germ cell tumors (EGCTs) in the lung are extremely rare and their pathogenesis is poorly understood. We report a case in a 48-year-old female which was very aggressive and stained positive for primoridial germ cell markers. Interestingly, there was chromosome 3 polysomy noted. To our knowledge this is the first chromosomal aberration noted in a primary germ cell tumor of the lung.
ISSN:1538-4047
1555-8576