Interim analysis of toxicity and response in phase 1 trial of systemic targeted alpha therapy for metastatic melanoma

• Published in: Cancer biology & therapy 2007-06, Vol.6 (6), p.846-852
• Main Authors: Raja, Chand, Graham, Peter, Rizvi, Syed, Song, Emma, Goldsmith, Helen, Thompson, John, Bosserhoff, Anja, Morgenstern, Alfred, Apostolidis, Christos, Kearsley, John, Reisfeld, Ralph, Allen, Barry J
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - toxicity; Antineoplastic Agents - therapeutic use; Binding; Biology; Biomarkers, Tumor; Bioscience; Calcium; Cancer; Cell; Cohort Studies; Cycle; Disease Progression; Female; Humans; Immunotherapy - methods; Landes; Male; Melanoma - drug therapy; Middle Aged; Neoplasm Metastasis; Organogenesis; Pentetic Acid - chemistry; Proteins; Tomography, Emission-Computed, Single-Photon
• ISSN: 1538-4047; 1555-8576
• DOI: 10.4161/cbt.6.6.4089

Purpose. The aim is to assess toxicity and response of systemic alpha therapy for metastatic melanoma. Experimental design. This is an open-labelled Phase 1 dose escalation study to establish the effective dose of the alpha-immunoconjugate 213Bi-cDTPA-9.2.27 mAb (AIC). Tools used to investigate the effects were physical examination; imaging of tumours; pathology; GFR; CT and changes in tumour marker. Responses were assessed using RECIST criteria. Results and Discussion. 22 patients with stage IV melanoma/ in-transit metastasis were treated with activities of 55-947 MBq. Using RECIST criteria 50% showed stable disease and 14% showed partial response. One patient (6%) showed near complete response and was retreated because of an excellent response to the initial treatment. Another patient showed response in his tumour on mandible and reduction in lung lesions. Overall 30% showed progressive disease. The tumour marker melanoma inhibitory activity protein (MIA) showed reductions over 8 weeks in most of the patients. The disparity of dose with responders is discussed. No toxicity was observed over the range of administered activities. Conclusion. Observation of responses without any toxicity indicates that targeted alpha therapy has the potential to be a safe and effective therapeutic approach for metastatic melanoma.