p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis

The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38δ in...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2010-02, Vol.9 (3), p.498-505
Main Author: Efimova, Tatiana
Format: Article
Language:English
Subjects:
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
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Summary:The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38δ in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.9.3.10541