Netrin-Integrin Signaling in Epithelial Morphogenesis, Axon Guidance and Vascular Patterning

Netrins and their classical receptors - DCC and neogenin - play key roles in neuronal guidance. Recent developments identify new roles for netrins in epithelial and vascular morphogenesis. Netrins accomplish these effects, at least in part, through binding to integrins and/or activating integrin-ass...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2005-03, Vol.4 (3), p.429-433
Main Authors: Nikolopoulos, Sotiris N., Giancotti, Filippo G.
Format: Article
Language:English
Subjects:
Animals
Axons - metabolism
Binding
Binding Sites
Biology
Bioscience
Body Patterning
Calcium
Cancer
Cell
Cell Differentiation
Cell Movement
Cycle
Epithelium - metabolism
Focal Adhesion Protein-Tyrosine Kinases - metabolism
Humans
Integrins - metabolism
Landes
Ligands
Mice
Models, Biological
Neovascularization, Physiologic
Nerve Growth Factors - metabolism
Netrin Receptors
Netrin-1
Neurons - metabolism
Organogenesis
Protein Binding
Proteins
Proto-Oncogene Proteins c-fyn - metabolism
Receptors, Cell Surface - metabolism
Signal Transduction
Tumor Suppressor Proteins - metabolism
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Summary:Netrins and their classical receptors - DCC and neogenin - play key roles in neuronal guidance. Recent developments identify new roles for netrins in epithelial and vascular morphogenesis. Netrins accomplish these effects, at least in part, through binding to integrins and/or activating integrin-associated kinases such as FAK and Fyn. Here we discuss these recent findings and propose that integrins and classical netrin receptors cooperate to regulate multiple aspects of development.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.4.3.1547