The INO80 Chromatin Remodeling Complex Functions in Sister Chromatid Cohesion

Here we identify a defect in sister chromatid cohesion in the Saccharomyces serevisiae arp8 mutant, which impairs the chromatin remodeling activity of the INO80 complex, and we report the direct association of Ino80 with centromeres and cohesin-associated regions. In early S phase, Ino80 is recruite...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2007-05, Vol.6 (9), p.1090-1095
Main Authors: Ogiwara, Hideaki, Enomoto, Takemi, Seki, Masayuki
Format: Article
Language:English
Subjects:
Benomyl - pharmacology
Binding
Binding Sites
Biology
Bioscience
Calcium
Cancer
Cell
Chromatin Assembly and Disassembly - drug effects
Chromatin Assembly and Disassembly - physiology
Cycle
DNA Replication
Kinetochores - metabolism
Landes
Microfilament Proteins - genetics
Microfilament Proteins - metabolism
Mutation
Organogenesis
Proliferating Cell Nuclear Antigen - metabolism
Proteins
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Sister Chromatid Exchange - physiology
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Summary:Here we identify a defect in sister chromatid cohesion in the Saccharomyces serevisiae arp8 mutant, which impairs the chromatin remodeling activity of the INO80 complex, and we report the direct association of Ino80 with centromeres and cohesin-associated regions. In early S phase, Ino80 is recruited to replication forks along with Ctf18 and PCNA, both of which are involved in the establishment of sister chromatid cohesion. The arp8 mutation perturbs the association of Ctf18 and PCNA but not of cohesin with replication forks. We propose that the INO80 complex is required for the proper establishment of sister chromatid cohesion.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.6.9.4130