Evidence of Mnt-Myc Antagonism Revealed by Mnt Gene Deletion

Myc proteins play a central role in promoting cell proliferation and contribute to a diverse array of cancers. Myc function appears completely dependent on heterodimerization with Max through related bHLHZip regions. Max interaction with Myc is required for DNA binding at so-called E-box sequences a...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2004-02, Vol.3 (2), p.95-97
Main Authors: Hurlin, Peter J., Zhou, Zi-Qiang, Toyo-oka, Kazuhito, Ota, Sara, Walker, William L., Hirotsune, Shinji, Wynshaw-Boris, Anthony
Format: Article
Language:English
Subjects:
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
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Summary:Myc proteins play a central role in promoting cell proliferation and contribute to a diverse array of cancers. Myc function appears completely dependent on heterodimerization with Max through related bHLHZip regions. Max interaction with Myc is required for DNA binding at so-called E-box sequences and Myc-dependent transcriptional activation. The identification of Mnt as a ubiquitously expressed Max-interacting transcriptional repressor with similar DNA binding specificity raised the possibility that Mnt may serve a general role as a Myc antagonist.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.3.2.638