MicroRNAs as regulators of epithelial-mesenchymal transition

Epithelial-mesenchymal transition (EMT) describes the molecular reprogramming and phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile mesenchymal cells. This process allows the remodelling of tissues during embryonic development and is implicated in the pro...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2008-10, Vol.7 (20), p.3112-3117
Main Authors: Gregory, Philip A., Bracken, Cameron P., Bert, Andrew G., Goodall, Gregory J.
Format: Article
Language:English
Subjects:
Binding
Biology
Biomarkers - metabolism
Bioscience
Calcium
Cancer
Cell
Cycle
Epithelium - physiology
Feedback, Physiological
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Humans
Landes
Mesoderm - physiology
MicroRNAs - genetics
MicroRNAs - metabolism
Neoplasms - physiopathology
Organogenesis
Phenotype
Proteins
Signal Transduction - physiology
Transcription Factors - genetics
Transcription Factors - metabolism
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Description
Summary:Epithelial-mesenchymal transition (EMT) describes the molecular reprogramming and phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile mesenchymal cells. This process allows the remodelling of tissues during embryonic development and is implicated in the promotion of tumor invasion and metastasis. Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. The miR-200 family participates in a signaling network with the E-cadherin transcriptional repressors ZEB1/δEF1 and ZEB2/SIP1, and TGF-β2 that is postulated to facilitate maintenance of stable epithelial or mesenchymal states but also allow reversible switching between these states in response to EMT effectors (such as TGF-β). This review summarizes these recent findings and their implications in both developmental EMT and tumor progression.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.7.20.6851