Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation

Dynamic acetylation and deacetylation of nuclear histones is essential for regulating the access of chromosomal DNA to transcriptional machinery. The source of acetyl-CoA for histone acetylation in mammalian cell nuclei is not clearly known. We show that acetylcarnitine formed in mitochondria, is tr...

Full description

Saved in:
Bibliographic Details
Published in:Epigenetics 2009-08, Vol.4 (6), p.399-403
Main Authors: Madiraju, Padma, Pande, Shri V, Prentki, Marc, Madiraju, S R Murthy
Format: Article
Language:English
Subjects:
Acetylation
Acetylcarnitine - metabolism
Acetylcarnitine - physiology
Active Transport, Cell Nucleus
Binding
Biology
Bioscience
Calcium
Cancer
Carnitine O-Acetyltransferase - metabolism
Cell
Cycle
Epigenesis, Genetic
Histones - metabolism
Landes
Mitochondria - metabolism
Models, Genetic
Organogenesis
Proteins
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dynamic acetylation and deacetylation of nuclear histones is essential for regulating the access of chromosomal DNA to transcriptional machinery. The source of acetyl-CoA for histone acetylation in mammalian cell nuclei is not clearly known. We show that acetylcarnitine formed in mitochondria, is transported into cytosol by carnitine/acylcarnitine translocase, and then enters nucleus, where it is converted to acetyl-CoA by a nuclear carnitine acetyltransferase and becomes a source of acetyl groups for histone acetylation. Genetic deficiency of the translocase markedly reduced the mitochondrial acetylcarnitine dependent nuclear histone acetylation, indicating the significance of the carnitine-dependent mitochondrial acetyl group contribution to histone acetylation.
ISSN:1559-2294
1559-2308
DOI:10.4161/epi.4.6.9767