The wolf in sheep's clothing: Platelet-derived "pseudo self" impairs cancer cell "missing self" recognition by NK cells

Metastasis is strongly inhibited in thrombocytopenic mice. This phenotype is reversed by NK cell depletion which indicates that platelets may facilitate tumor progression and metastasis by interfering with NK cell immunosurveillance. Understanding the underlying mechanisms may help us to reinforce a...

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Bibliographic Details
Published in:Oncoimmunology 2012-07, Vol.1 (4), p.557-559
Main Authors: Placke, Theresa, Kopp, Hans-Georg, Salih, Helmut Rainer
Format: Article
Language:English
Subjects:
Author's View
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
metastasis
MHC class I
NK cells
Organogenesis
platelets
Proteins
thrombocytes
tumor immunosurveillance
Citations: Items that this one cites
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Description
Summary:Metastasis is strongly inhibited in thrombocytopenic mice. This phenotype is reversed by NK cell depletion which indicates that platelets may facilitate tumor progression and metastasis by interfering with NK cell immunosurveillance. Understanding the underlying mechanisms may help us to reinforce anti-tumor immunity and NK-based immunotherapy in cancer patients.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.19367