How helminths use excretory secretory fractions to modulate dendritic cells

It is well known that helminth parasites have immunomodulatory effects on their hosts. They characteristically cause a skew towards TH2 immunity, stimulate Treg cells while simultaneously inhibiting TH1 and TH17 responses. Additionally, they also induce eosinophilia and extensive IgE release. The ex...

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Bibliographic Details
Published in:Virulence 2012-11, Vol.3 (7)
Main Authors: Rhiannon R. White, Katerina Artavanis-Tsakonas
Format: Article
Language:English
Subjects:
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
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Summary:It is well known that helminth parasites have immunomodulatory effects on their hosts. They characteristically cause a skew towards TH2 immunity, stimulate Treg cells while simultaneously inhibiting TH1 and TH17 responses. Additionally, they also induce eosinophilia and extensive IgE release. The exact mechanism of how the worms achieve this effect have yet to be fully elucidated, however parasite-derived secretions and their interaction with antigen presenting cells have been centrally implicated. Herein, we will review the effects of helminth excretory-secretory fractions on dendritic cells and discuss how this interaction is crucial in shaping the host response.
ISSN:2150-5594
2150-5608