A simple one-pot preparation of N-allenyl amides, ureas, carbamates and sulfonamides using a DMSO/tBuOK protocol

A one-pot transformation of amides, ureas, carbamates and sulfonamides into synthetically useful N-allenyl analogues using a tBuOK/DMSO protocol is reported. The procedure is experimentally simple and robust, and provides N-allenyl analogues, commonly used within the literature, in yields comparable...

Full description

Saved in:
Bibliographic Details
Main Authors: Thomas W. Bousfield, Marc Kimber
Format: Article
Language:English
Subjects:
Allenamide
Amide
Chemical Sciences not elsewhere classified
Lactam
One-pot
Organic Chemistry
Organic chemistry not elsewhere classified
Other chemical sciences not elsewhere classified
Propargyl bromide
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A one-pot transformation of amides, ureas, carbamates and sulfonamides into synthetically useful N-allenyl analogues using a tBuOK/DMSO protocol is reported. The procedure is experimentally simple and robust, and provides N-allenyl analogues, commonly used within the literature, in yields comparable to the benchmark two-step approach.