Towards a total synthesis of the manadomanzamine alkaloids: the first asymmetric construction of the pentacyclic indole core

We report a highly diastereoselective approach for the synthesis of the pentacyclic indole core of the manadomanzamine alkaloid skeleton, with complete control over the relative and absolute stereochemistries at the three contiguous stereocentres at ring positions 1, 10, and 24, from a readily avail...

Full description

Saved in:
Bibliographic Details
Main Authors: Steven Allin, Liam J. Duffy, Philip C. Bulman Page, Vickie McKee, Michael J. McKenzie
Format: Article
Language:English
Subjects:
Chemical Sciences not elsewhere classified
Organic Chemistry
Organic chemistry not elsewhere classified
Other chemical sciences not elsewhere classified
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a highly diastereoselective approach for the synthesis of the pentacyclic indole core of the manadomanzamine alkaloid skeleton, with complete control over the relative and absolute stereochemistries at the three contiguous stereocentres at ring positions 1, 10, and 24, from a readily available chiral template.