Elevations of blood pressure and plasma catecholamines in rat with hyperparathyroidism

Previously, we demonstrated that the hypertension developed in rats fed alow calcium diet ( LCaD ) was bas ed on a chronically enhanced parathyroid function. In this experiment, we examined the relationship between catecholamines , blood pressure and parathyroid function. The plasma and adrenal cate...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1988, Vol.46 (suppl), p.272-272
Main Authors: Akifumi Togari, Michitsugu Arai, Shosei Matsumoto, Masako Hagihara, Toshiharu Nagatsu
Format: Article
Language:Japanese
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Summary:Previously, we demonstrated that the hypertension developed in rats fed alow calcium diet ( LCaD ) was bas ed on a chronically enhanced parathyroid function. In this experiment, we examined the relationship between catecholamines , blood pressure and parathyroid function. The plasma and adrenal catecholamines ( NE , EN )levels and adrenal catecholamine synthesizing enzymes activities were measured by HPLC-ECD. The elevation of blood pressure in rat fed a LCaD was accompanied with significant increases of catecholamines in plasma. and with significant decreases of catecholamines in adrenal. In parathyroidectomized rats , elevations of blood pressure and catecholamines levels in plasma were not observed .Increases of tyrosine hydroxylase and dopamine beta-hydroxylase activities in adrenal were observed in rat fed a LCaD but not in parathyroidectomized rats. This evidence may suggest that enhanced parathyroid function increases the catecholamine release and synthesis in adrenal and that catecholamine system is involved in the elevation of blood pressure in rats with hyperparathyroidism.
ISSN:0021-5198