Pharmacological activities of synthetic human cholecystokinin-33 (CCK-33) of which tyrosine was sulfated by arylsulfotransferase (AST)

We have examined the activities of synthetic human CCK-33 in comparison with those of non-sulfated CCK-33 (CCX-33NS), CCK-8 and CCE-4 by several pharmacological methods. CCK-33 was about 100-fold more potent than CCK-33NS and was about 20-fold less potent than CCK-8 in the contractive activity of th...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1989, Vol.49 (suppl), p.90-90
Main Authors: Masaki Hagiwara, Eiko Ohuchi, Kazuya Hongo, Miyuki Oki, Masaharu Nakano, Masahide Amemiya, Tadanori Morikawa, Kyoichi Kobashi
Format: Article
Language:Japanese
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Summary:We have examined the activities of synthetic human CCK-33 in comparison with those of non-sulfated CCK-33 (CCX-33NS), CCK-8 and CCE-4 by several pharmacological methods. CCK-33 was about 100-fold more potent than CCK-33NS and was about 20-fold less potent than CCK-8 in the contractive activity of the isolated gallbladder of the guinea-pig. In pancreatic secretion of the rat, intravenous CCK-33 and CCk-8 showed almost the same activity. Their potencies were about 1000-fold more than those of CCK-33NS, non-sulfated CCK-8 (CCK-8NS) or CCK-4. CCk-33 and CCK-8 produced a reduction in the food intake at the doses of 10-8 and 3×10-8 M/kg, i.p., but CCK-33NS, CCk-8NS and CCK-4 did not. There were not much differences in the gastric acid stimulatory activities of CCK-33, CCK-8 and CCk-4, but the activities of CCK-33NS and CCK-8NS were less than those of CCK-33 and CCK-8, respectively.
ISSN:0021-5198