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Effects of Endothelin, an endothelium derived vasoconstrictor peptide on two kinds of veins of the dog

Endothelin has been shown to exert a potent and long-lasting vasoconstrictor action on various kinds of arteries. In the present study, the effects of Endothelin on the veins were investigated in vitro. Two kinds of embryologically distinct canine veins were employed:portal and inferior vena cava, r...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1989, Vol.49 (suppl), p.287-287
Main Authors: Akemi Hayakawa, Minoru Kawanishi, Yasuhiro Shilada, Katsutoshi Goto
Format: Article
Language:Japanese
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Summary:Endothelin has been shown to exert a potent and long-lasting vasoconstrictor action on various kinds of arteries. In the present study, the effects of Endothelin on the veins were investigated in vitro. Two kinds of embryologically distinct canine veins were employed:portal and inferior vena cava, representing the digestive system, and the femoral and jugular veins, representing the body wall. Helical strips of the vein were suspended in organ baths containing Krebs-Henseleit solution sassed with 95%O2 +5% CO2 and maintained at 37℃, and isometric tensions were recorded. The data were expressed as a percentage of the maximum response to K+ (80 mM) for normalization. Endo-thelin showed potent vasoconstrictor actions on both kinds of veins. with an ED50 value of 1×10-9 M. Endothelin-induced contractions were attenuated by a low concentration of nicardipine (1×10-8 M). The results showed that Endothelin exerts strong vasoconstrictor actions not only on the arteries but also on the veins, indicating that endothelin might. be a generalized vasoconstrictor.
ISSN:0021-5198