Low Ca^2+ plus Tetraethylammonium Medium

The low Ca^2+ + tetraethylammonium (TEA) medium enhanced electrically evoked norepinephrine release by 3.5-fold in canine saphenous veins. ω-Conotoxin GVIA (ω-CTX) inhibited the neurotransmission more markedly in low Ca^2+ + TEA medium than in normal Krebs medium. This is the case for the inhibition...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1991, Vol.56 (4), p.535-538
Main Authors: Yoshinobu Takata, Junko Ozawa, Hitoshi Kato
Format: Article
Language:Japanese
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Summary:The low Ca^2+ + tetraethylammonium (TEA) medium enhanced electrically evoked norepinephrine release by 3.5-fold in canine saphenous veins. ω-Conotoxin GVIA (ω-CTX) inhibited the neurotransmission more markedly in low Ca^2+ + TEA medium than in normal Krebs medium. This is the case for the inhibition by tetrodotoxin, though to a lesser extent. The inhibition by ω-CTX was competitively antagonized by elevating external Ca^2+ . The results indicate that low Ca^2+ + TEA medium is useful for studying the effect of Ca antagonists on adrenergic neurotransmission, because ω-CTX acts more effectively in this medium.
ISSN:0021-5198