Vasodilator and cardioprotective effects of a novel agent, 7-O-ethylfangchinoline in isolated tissues

The effects of 7-O-ethylfangchinoline (TJN-220) on rat perfused hearts were examined. TJN-220 decreased the left ventricular pressure (LVP) dose-dependently, and was equieffective to diltiazem at 10^-5 M. The pressure-rate product (HR x LVP) obtained with TJN-220 was smaller than that with diltiazem...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1992, Vol.58 (suppl.2), p.397-397
Main Authors: Kiyoshi Fukuyama, Toshitsugu Sato, Tatsunori Ogino, Masao ChinZhengxiong Chen, Hiroshi Mitsuhashi
Format: Article
Language:Japanese
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Summary:The effects of 7-O-ethylfangchinoline (TJN-220) on rat perfused hearts were examined. TJN-220 decreased the left ventricular pressure (LVP) dose-dependently, and was equieffective to diltiazem at 10^-5 M. The pressure-rate product (HR x LVP) obtained with TJN-220 was smaller than that with diltiazem. TJN-220 produced a concentration-dependent relaxation in rat thoracic aorta contracted with 30 mM KCl or Bay K 8644 (3 x 10^-7 M). TJN-220, unlike diltiazem and nifedipine, also relaxed rat thoracic aorta contracted with the Ca^++ ionophor, A 23187. These results suggest that TJN-220 may have both Ca^++ entry blocking and anti-Ca^++ ionophor actions in the vessels and heart and that it may have vasodilator and cardioprotective effects.
ISSN:0021-5198